Which of the following antibiotics also has an interaction with calcium channel blockers?

The correct choice is doxycycline, which is a member of the tetracycline class of antibiotics. Doxycycline has a known interaction with calcium channel blockers due to its effect on the metabolism of these medications. Specifically, doxycycline can inhibit certain enzymes that metabolize calcium channel blockers, potentially leading to increased levels of these drugs in the body and an enhanced risk of side effects.

Tetracycline, while also interacting with calcium ion levels in general, is not typically noted for a significant pharmacokinetic interaction with calcium channel blockers specifically.

Clindamycin and metronidazole do not have notable interactions with calcium channel blockers, making them unrelated to the context of this particular interaction. As a result, the emphasis on doxycycline reflects its unique pharmacological profile and importance in this specific interaction scenario. Understanding these interactions helps prevent potential adverse effects and ensures safe combination therapy in clinical practice.